SCHEMBL8323808

SCHEMBL8323808

COC(=O)c1ccc(CCc2cc(Br)ccc2OCc2ccccc2)nc1Cl

nearest known ligand 0.47

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CCR5 P51681 4/20 0.47
PTGER1 P34995 6/20 0.46
CYP1A2 P05177 1/20 0.46
ALDH1A1 P00352 2/20 0.46
USP28 Q96RU2 1/20 0.46
USP25 Q9UHP3 1/20 0.46
RAB9A P51151 1/20 0.46
LRRK2 Q5S007 2/20 0.46
LMNA P02545 2/20 0.45
HTT P42858 2/20 0.45
USP2 O75604 1/20 0.44
MTNR1A P48039 1/20 0.44
MTNR1B P49286 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8326037 0.89 CCR5 (0.46) CCR5PTGER1CYP1A2ALDH1A1USP28
SCHEMBL8321883 0.88 PTGER1 (0.47) CCR5PTGER1CYP1A2ALDH1A1USP28
SCHEMBL8324805 0.83 PTGER1 (0.49) CCR5PTGER1CYP1A2ALDH1A1USP28
SCHEMBL8324992 0.82 CCR5 (0.48) CCR5PTGER1CYP1A2ALDH1A1USP28
SCHEMBL8322935 0.81 CCR5 (0.49) CCR5PTGER1CYP1A2ALDH1A1USP28
SCHEMBL8325570 0.81 PTGER1 (0.50) CCR5PTGER1CYP1A2ALDH1A1USP28
SCHEMBL8325136 0.81 ABCB1 (0.51) CCR5PTGER1CYP1A2ALDH1A1USP28
SCHEMBL8326541 0.81 LRRK2 (0.47) CCR5PTGER1CYP1A2ALDH1A1USP28
SCHEMBL8324940 0.78 CCR5 (0.53) CCR5PTGER1CYP1A2ALDH1A1USP28
SCHEMBL8409537 0.78 CCR5 (0.53) CCR5PTGER1CYP1A2ALDH1A1USP28

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0733033-B1 PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS ZENECA LTD (GB) 1999-12-22 EP disclosed
US-5811459-A PAIN RELIEVERS ZENECA LIMITED (GB) 1998-09-22 US disclosed
EP-0733033-A1 PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS ZENECA LIMITED (GB) 1996-09-25 EP disclosed
WO-1996011902-A1 PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS ZENECA LIMITED (GB) 1996-04-25 WO disclosed