Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 5/20 | 0.35 |
| ▸ | CA1 | P00915 | 3/20 | 0.34 |
| ▸ | CA2 | P00918 | 3/20 | 0.34 |
| ▸ | CA7 | P43166 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | GLA | P06280 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8321322 | 0.88 | KMT2A (0.39) | KMT2AKDM4ENPSR1MAPTLMNA | |
| SCHEMBL8318492 | 0.86 | LMNA (0.44) | KMT2AKDM4ENPSR1MAPTSIRT1 | |
| SCHEMBL8320521 | 0.85 | KMT2A (0.38) | KMT2AKDM4ENPSR1MAPTLMNA | |
| SCHEMBL8318029 | 0.84 | ALDH1A1 (0.46) | KMT2AKDM4ENPSR1MAPTSIRT1 | |
| SCHEMBL8323456 | 0.80 | TSHR (0.39) | KMT2AKDM4ENPSR1MAPTLMNA | |
| SCHEMBL8320504 | 0.78 | CYP2C9 (0.37) | KMT2AKDM4ENPSR1MAPTLMNA | |
| SCHEMBL9046285 | 0.75 | KMT2A (0.45) | KMT2AKDM4ENPSR1MAPTLMNA | |
| SCHEMBL8320047 | 0.71 | KDM4E (0.48) | KDM4ENPSR1MAPTSIRT1LMNA | |
| SCHEMBL8317255 | 0.71 | GAA (0.45) | KMT2AKDM4ENPSR1MAPTGAA | |
| SCHEMBL8080963 | 0.69 | KMT2A (0.47) | KMT2AKDM4ENPSR1LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0717043-B1 | Use of 1,2-bridged 1,4-dihydropyridines as selective potassium channel modulators | BAYER AG (DE) | 1999-11-10 | — | — | EP | claimed |
| EP-0717043-A1 | Use of 1,2-bridged 1,4-dihydropyridines as selective potassium channel modulators | BAYER AG (DE) | 1996-06-19 | — | — | EP | claimed |