Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | CASP1 | P29466 | 3/20 | 0.46 |
| ▸ | CASP7 | P55210 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 4/20 | 0.42 |
| ▸ | CA2 | P00918 | 4/20 | 0.42 |
| ▸ | CA7 | P43166 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8317255 | 0.87 | GAA (0.45) | ALDH1A1KDM4EGAACASP1CASP7 | |
| SCHEMBL8320047 | 0.85 | KDM4E (0.48) | ALDH1A1KDM4EGAACASP1CASP7 | |
| SCHEMBL8318729 | 0.84 | GAA (0.44) | ALDH1A1KDM4EGAACASP1CASP7 | |
| SCHEMBL8325253 | 0.84 | KMT2A (0.39) | ALDH1A1KDM4EGAACASP1CASP7 | |
| SCHEMBL8468645 | 0.79 | HPGD (0.43) | ALDH1A1KDM4EGAACASP1CASP7 | |
| SCHEMBL8321061 | 0.76 | HPGD (0.41) | ALDH1A1KDM4EGAACASP1CASP7 | |
| SCHEMBL8319383 | 0.76 | HPGD (0.43) | ALDH1A1KDM4EGAACASP1CASP7 | |
| SCHEMBL8319794 | 0.72 | POLB (0.47) | ALDH1A1KDM4EGAACASP1CASP7 | |
| SCHEMBL8318492 | 0.71 | LMNA (0.44) | ALDH1A1KDM4EGAACASP1CASP7 | |
| SCHEMBL8321322 | 0.70 | KMT2A (0.39) | ALDH1A1KDM4EGAACASP1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0717043-B1 | Use of 1,2-bridged 1,4-dihydropyridines as selective potassium channel modulators | BAYER AG (DE) | 1999-11-10 | — | — | EP | claimed |
| EP-0717043-A1 | Use of 1,2-bridged 1,4-dihydropyridines as selective potassium channel modulators | BAYER AG (DE) | 1996-06-19 | — | — | EP | claimed |