Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 2/20 | 0.55 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.55 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.55 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.55 |
| ▸ | HTR1A | P08908 | 4/20 | 0.51 |
| ▸ | DRD2 | P14416 | 4/20 | 0.51 |
| ▸ | ABCB1 | P08183 | 9/20 | 0.48 |
| ▸ | MGLL | Q99685 | 1/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.42 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8408170 | 0.93 | HTR1A (0.61) | PTGER1PTGER4PTGER3PTGER2HTR1A | |
| SCHEMBL8320664 | 0.93 | HTR1A (0.61) | PTGER1PTGER4PTGER3PTGER2HTR1A | |
| SCHEMBL8323974 | 0.86 | HTR1A (0.43) | PTGER1PTGER4PTGER3PTGER2HTR1A | |
| SCHEMBL8325042 | 0.86 | ABCB1 (0.46) | PTGER1PTGER4PTGER3PTGER2HTR1A | |
| SCHEMBL8409574 | 0.81 | HTR1A (0.45) | PTGER1PTGER4PTGER3PTGER2HTR1A | |
| SCHEMBL8321903 | 0.81 | HTR1A (0.48) | PTGER1PTGER4PTGER3PTGER2HTR1A | |
| SCHEMBL8323370 | 0.81 | ABCB1 (0.50) | HTR1ADRD2ABCB1ABCG2HTT | |
| SCHEMBL6962342 | 0.81 | MAOB (0.43) | — | |
| SCHEMBL8322241 | 0.80 | HTR1A (0.44) | PTGER1HTR1ADRD2ABCB1ABCG2 | |
| SCHEMBL8405902 | 0.80 | HTR1A (0.44) | PTGER1HTR1ADRD2ABCB1ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733033-B1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LTD (GB) | 1999-12-22 | — | — | EP | disclosed |
| EP-0733033-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-09-25 | — | — | EP | disclosed |
| WO-1996011902-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-04-25 | — | — | WO | disclosed |