SCHEMBL8323974

SCHEMBL8323974

Brc1cc(-c2nnn[nH]2)ccc1CCCc1ccccc1OCc1ccccc1

nearest known ligand 0.43

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
HTR1A P08908 4/20 0.43
DRD2 P14416 4/20 0.43
PTGER1 P34995 3/20 0.42
PTGER4 P35408 3/20 0.42
PTGER3 P43115 3/20 0.42
PTGER2 P43116 3/20 0.42
ABCB1 P08183 7/20 0.41
MGLL Q99685 1/20 0.40
DHFR P00374 1/20 0.36
ABCG2 Q9UNQ0 1/20 0.36
PRMT5 O14744 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8321903 0.96 HTR1A (0.48) HTR1ADRD2PTGER1PTGER4PTGER3
SCHEMBL8325042 0.88 ABCB1 (0.46) HTR1ADRD2PTGER1PTGER4PTGER3
SCHEMBL8325617 0.86 PTGER1 (0.55) HTR1ADRD2PTGER1PTGER4PTGER3
SCHEMBL8323370 0.83 ABCB1 (0.50) HTR1ADRD2ABCB1ABCG2
SCHEMBL8408170 0.81 HTR1A (0.61) HTR1ADRD2PTGER1PTGER4PTGER3
SCHEMBL8320664 0.81 HTR1A (0.61) HTR1ADRD2PTGER1PTGER4PTGER3
SCHEMBL8409051 0.76 CCR5 (0.45) HTR1ADRD2PTGER1ABCB1ABCG2
SCHEMBL8320385 0.76 CCR5 (0.45) HTR1ADRD2PTGER1ABCB1ABCG2
SCHEMBL8322255 0.74 ABCB1 (0.43) HTR1ADRD2PTGER1ABCB1ABCG2
SCHEMBL1055391 0.74 PRMT5 (0.47) PRMT5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0733033-B1 PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS ZENECA LTD (GB) 1999-12-22 EP claimed
EP-0733033-A1 PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS ZENECA LIMITED (GB) 1996-09-25 EP claimed
WO-1996011902-A1 PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS ZENECA LIMITED (GB) 1996-04-25 WO claimed
EP-0733033-B1 PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS ZENECA LTD (GB) 1999-12-22 EP disclosed
US-5811459-A PAIN RELIEVERS ZENECA LIMITED (GB) 1998-09-22 US disclosed
EP-0733033-A1 PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS ZENECA LIMITED (GB) 1996-09-25 EP disclosed
WO-1996011902-A1 PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS ZENECA LIMITED (GB) 1996-04-25 WO disclosed