Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8326904 | 0.79 | EDNRA (0.48) | EDNRA | |
| SCHEMBL7018075 | 0.79 | EDNRA (0.48) | EDNRAMAPTPIK3CAMTORALDH1A1 | |
| SCHEMBL7012433 | 0.78 | EDNRA (0.47) | EDNRAMAPTPIK3CAMTORALDH1A1 | |
| SCHEMBL7013707 | 0.77 | EDNRA (0.45) | EDNRAMAPTPIK3CAMTORALDH1A1 | |
| SCHEMBL7013473 | 0.76 | EDNRA (0.44) | EDNRAMAPTPIK3CAMTORALDH1A1 | |
| SCHEMBL7009897 | 0.75 | EDNRA (0.43) | EDNRAMAPTPIK3CAMTORALDH1A1 | |
| SCHEMBL8326002 | 0.74 | EDNRA (0.77) | EDNRA | |
| SCHEMBL7006907 | 0.73 | EDNRA (0.42) | EDNRAMAPTPIK3CAMTORALDH1A1 | |
| SCHEMBL7598526 | 0.72 | KMT2A (0.40) | EDNRAMAPTALDH1A1HPGDKMT2A | |
| SCHEMBL7322839 | 0.71 | EDNRA (0.42) | EDNRAMAPTHPGDKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0633259-B1 | Sulfonylaminopyrimidines, their preparation and their use as medicine | HOFFMANN LA ROCHE (CH) | 1999-01-13 | — | — | EP | disclosed |
| EP-0633259-A1 | Sulfonylaminopyrimidines, their preparation and their use as medicine | F. HOFFMANN-LA ROCHE AG (CH) | 1995-01-11 | — | — | EP | disclosed |