Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 4/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | IDO2 | Q6ZQW0 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7429108 | 0.79 | IDO1 (0.50) | SLC6A2SLC6A4CYP2D6SLC6A3KCNH2 | |
| SCHEMBL8324166 | 0.78 | ACP3 (0.47) | SLC6A2SLC6A4IDO1TDO2HTT | |
| SCHEMBL7430169 | 0.75 | CYP19A1 (0.44) | SLC6A4CYP2D6CYP3A4CYP1A2CYP2C9 | |
| SCHEMBL8325499 | 0.74 | IDO1 (0.49) | SLC6A2SLC6A4IDO1TDO2 | |
| SCHEMBL13126260 | 0.74 | SLC6A2 (0.48) | SLC6A2SLC6A4CYP2D6SLC6A3CYP3A4 | |
| SCHEMBL94275 | 0.74 | HTR2A (0.52) | RAB9ATDP1TSHR | |
| SCHEMBL8327006 | 0.73 | SLC6A2 (0.48) | SLC6A2SLC6A4CYP2D6SLC6A3CYP3A4 | |
| SCHEMBL16950377 | 0.73 | SLC6A2 (0.47) | SLC6A2SLC6A4CYP2D6SLC6A3CYP3A4 | |
| SCHEMBL16960998 | 0.73 | SLC6A2 (0.43) | SLC6A2SLC6A4CYP2D6SLC6A3CYP3A4 | |
| SCHEMBL4635178 | 0.72 | TSHR (0.44) | SLC6A4CYP2D6SLC6A3CYP3A4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948496-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDONE COMPOUNDS AND METHODS OF USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998024780-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDINONE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |