Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | GSK3A | P49840 | 1/20 | 0.45 |
| ▸ | SGMS2 | Q8NHU3 | 4/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8327267 | 0.89 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL8318915 | 0.88 | NPC1 (0.50) | NPC1RAB9AALDH1A1LMNANPSR1 | |
| SCHEMBL8320435 | 0.83 | PDE4D (0.50) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5022728 | 0.83 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL8325539 | 0.83 | ALDH1A1 (0.50) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL8325509 | 0.78 | GAA (0.49) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL8324499 | 0.77 | CNR2 (0.35) | PDE4APDE4BPDE4CPDE4DHTR2A | |
| SCHEMBL8324668 | 0.73 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL5017972 | 0.72 | CYP19A1 (0.51) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL8318940 | 0.72 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4DNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004069831-A1 | TRICYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION | GLENMARK PHARMACEUTICALS LTD. (US) | 2004-08-19 | — | — | WO | disclosed |