Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMP | P19971 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.33 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.33 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | TXN | P10599 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6081038 | 0.81 | AHR (0.41) | PTGS2HSD17B10KDM4E | |
| SCHEMBL9784280 | 0.77 | ACHE (0.40) | PTGS2ARPTGS1MAPK14KDM4E | |
| SCHEMBL28014952 | 0.77 | KIF11 (0.43) | — | |
| SCHEMBL20108650 | 0.76 | TYMP (0.42) | TYMPPTGS2NPC1RAB9ATP53 | |
| SCHEMBL7460316 | 0.76 | CYP2A6 (0.42) | TYMPPTGS2SMN1; SMN2TSHRPTGS1 | |
| SCHEMBL4453498 | 0.76 | TYMP (0.38) | TYMPPTGS2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9646884 | 0.75 | TAAR1 (0.41) | GRM5KDM4E | |
| SCHEMBL27488947 | 0.74 | CYP2A6 (0.41) | TYMPPTGS2SMN1; SMN2TSHRPTGS1 | |
| SCHEMBL9529038 | 0.74 | MMP3 (0.43) | TSHRAR | |
| SCHEMBL5198266 | 0.74 | AHR (0.36) | TYMPPTGS2NPC1RAB9ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948496-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDONE COMPOUNDS AND METHODS OF USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998024780-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDINONE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |
| US-5120848-A | Anticholesterol and antilipemic agents; hydroxy-3-methylglutaryl/3-/ coenzyme A reductase inhibitors | GLAXO GROUP LIMITED (GB) | 1992-06-09 | — | — | US | disclosed |
| US-5013749-A | Imidazole derivatives and their use as hypercholesterolemia and hyperlipoproteinemia agents | GLAXO GROUP LIMITED (GB) | 1991-05-07 | — | — | US | disclosed |