Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 12/20 | 0.47 |
| ▸ | CCR5 | P51681 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.40 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.39 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8675246 | 0.85 | LRRK2 (0.44) | LRRK2CCR5HTTALDH1A1SMN1; SMN2 | |
| SCHEMBL8323808 | 0.81 | CCR5 (0.47) | LRRK2CCR5HTTALDH1A1SMN1; SMN2 | |
| SCHEMBL8321883 | 0.81 | PTGER1 (0.47) | LRRK2CCR5HTTALDH1A1SMN1; SMN2 | |
| SCHEMBL11561500 | 0.77 | LRRK2 (0.63) | LRRK2PTGER1 | |
| SCHEMBL11560468 | 0.74 | MET (0.52) | LRRK2 | |
| SCHEMBL8324805 | 0.74 | PTGER1 (0.49) | LRRK2CCR5HTTALDH1A1PTGER1 | |
| SCHEMBL8325570 | 0.74 | PTGER1 (0.50) | CCR5HTTALDH1A1SMN1; SMN2PTGER1 | |
| SCHEMBL8326543 | 0.74 | LRRK2 (0.36) | LRRK2 | |
| SCHEMBL11555954 | 0.74 | LRRK2 (0.54) | LRRK2 | |
| SCHEMBL11563128 | 0.73 | LRRK2 (0.63) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733033-B1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LTD (GB) | 1999-12-22 | — | — | EP | disclosed |
| WO-1996011902-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-04-25 | — | — | WO | disclosed |