Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.33 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | UBE2M | P61081 | 1/20 | 0.32 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.32 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.31 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.31 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.31 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.31 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8326704 | 0.81 | SIGMAR1 (0.47) | SIGMAR1HRH3MEN1KMT2A | |
| SCHEMBL8325794 | 0.80 | PIK3CD (0.43) | NAMPTHRH3 | |
| SCHEMBL11570592 | 0.79 | — | — | |
| SCHEMBL20801740 | 0.79 | GRIN2D (0.37) | SIGMAR1SLC18A3NAMPTGRIN2DGRIN3B | |
| SCHEMBL19622374 | 0.79 | SHBG (0.39) | SIGMAR1SLC18A3NAMPTGRIN2DGRIN3B | |
| SCHEMBL11911619 | 0.77 | RBP1 (0.38) | SIGMAR1GRIN2DGRIN3BADRA1DADRA1A | |
| SCHEMBL22550643 | 0.76 | UBE2M (0.35) | SIGMAR1SLC18A3UBE2MDCUN1D1HRH3 | |
| SCHEMBL22550363 | 0.76 | UBE2M (0.35) | SIGMAR1SLC18A3UBE2MDCUN1D1HRH3 | |
| SCHEMBL11911609 | 0.76 | HRH3 (0.38) | SIGMAR1SLC18A3NAMPTUBE2MDCUN1D1 | |
| SCHEMBL22856535 | 0.76 | GRIN2D (0.33) | SIGMAR1GRIN2DGRIN3BADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0604494-B1 | 5-HT4 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1999-07-28 | — | — | EP | disclosed |
| CN-1040436-C | Pharmaceuticals | SMITHKLINE BEECHAM PLC (GB) | 1998-10-28 | — | — | CN | disclosed |
| CN-1073173-A | Preparation method as the compound of 5-hydroxytryptamine receptor antagonist | SMITHKLINE BEECHAM PLC (GB) | 1993-06-16 | — | — | CN | disclosed |