Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 7/20 | 0.38 |
| ▸ | EDNRB | P24530 | 6/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | BRS3 | P32247 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6580603 | 0.86 | EDNRA (0.47) | EDNRAEDNRBHPGDSMN1; SMN2KDM4E | |
| SCHEMBL8329451 | 0.85 | EDNRA (0.42) | EDNRAEDNRBHPGDSMN1; SMN2KDM4E | |
| SCHEMBL6580607 | 0.85 | EDNRA (0.42) | EDNRAEDNRBHPGDSMN1; SMN2KDM4E | |
| SCHEMBL7506559 | 0.77 | BRS3 (0.40) | EDNRAHPGDSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL6588042 | 0.77 | BRS3 (0.40) | EDNRAHPGDSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL3838481 | 0.76 | HSP90AA1 (0.37) | EDNRAHPGDSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL6581992 | 0.73 | MEN1 (0.42) | EDNRAEDNRBHPGDSMN1; SMN2KDM4E | |
| SCHEMBL8435290 | 0.73 | EDNRA (0.47) | EDNRAEDNRBHPGDSMN1; SMN2KDM4E | |
| SCHEMBL8049350 | 0.72 | ALDH1A1 (0.38) | EDNRAHPGDSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL7498870 | 0.72 | EDNRA (0.59) | EDNRAEDNRBHPGDSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0461677-B1 | Novel thiazolidine derivatives | ONO PHARMACEUTICAL CO (JP) | 1997-04-16 | — | — | EP | claimed |
| US-5856509-A | HYPOTENSIVE AGENTS | ROUSSEL UCLAF (FR) | 1999-01-05 | — | — | US | disclosed |