Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.41 |
| ▸ | TUBB | P07437 | 2/20 | 0.41 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.41 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.41 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.41 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.41 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.41 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.41 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7374111 | 0.85 | TUBB4A (0.50) | MTNR1AMTNR1BPOLBTSHRHSD17B10 | |
| SCHEMBL6961103 | 0.84 | KMT2A (0.50) | MTNR1AMTNR1BPOLBTSHRSMN1; SMN2 | |
| SCHEMBL20448478 | 0.79 | IDO1 (0.44) | POLBSMN1; SMN2KMT2AHTTMEN1 | |
| SCHEMBL28338828 | 0.77 | KMT2A (0.50) | MTNR1AMTNR1BPOLBTSHRSMN1; SMN2 | |
| SCHEMBL7617760 | 0.76 | POLB (0.47) | MTNR1AMTNR1BPOLBTSHRSMN1; SMN2 | |
| SCHEMBL20499480 | 0.74 | ALDH1A1 (0.57) | POLBSMN1; SMN2KMT2AMEN1MAPT | |
| SCHEMBL2069250 | 0.74 | MTNR1A (0.54) | MTNR1AMTNR1BPOLBTSHRSMN1; SMN2 | |
| SCHEMBL2069756 | 0.74 | MTNR1A (0.54) | MTNR1AMTNR1BPOLBTSHRSMN1; SMN2 | |
| SCHEMBL5962399 | 0.74 | CA1 (0.50) | MTNR1AMTNR1BPOLBTSHRKMT2A | |
| SCHEMBL2069759 | 0.73 | KMT2A (0.50) | MTNR1AMTNR1BPOLBTSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0633259-B1 | Sulfonylaminopyrimidines, their preparation and their use as medicine | HOFFMANN LA ROCHE (CH) | 1999-01-13 | — | — | EP | disclosed |
| EP-0633259-A1 | Sulfonylaminopyrimidines, their preparation and their use as medicine | F. HOFFMANN-LA ROCHE AG (CH) | 1995-01-11 | — | — | EP | disclosed |