Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | RBP4 | P02753 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6153433 | 0.82 | PDE2A (0.44) | NPC1POLBTRPM8GAARBP4 | |
| SCHEMBL17865261 | 0.81 | LRRK2 (0.40) | NPC1POLBTRPM8RBP4CYP11B2 | |
| SCHEMBL12029013 | 0.80 | RPS6KA3 (0.39) | NPC1POLBTRPM8ALDH1A1L3MBTL1 | |
| SCHEMBL29435625 | 0.80 | RPS6KA3 (0.39) | NPC1POLBTRPM8ALDH1A1L3MBTL1 | |
| SCHEMBL8546018 | 0.79 | TNF (0.38) | NPC1POLBGAARBP4ALDH1A1 | |
| SCHEMBL24988696 | 0.77 | ALDH1A1 (0.35) | NPC1POLBTRPM8GAARBP4 | |
| SCHEMBL26272326 | 0.77 | ALDH1A1 (0.35) | NPC1POLBTRPM8GAARBP4 | |
| SCHEMBL19997547 | 0.74 | LIMK1 (0.36) | ALDH1A1MAPT | |
| SCHEMBL6155126 | 0.74 | TRPM8 (0.34) | NPC1POLBTRPM8RBP4CYP11B2 | |
| SCHEMBL20772453 | 0.73 | KIF11 (0.41) | NPC1POLBGAACYP11B2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0758321-B1 | 3-SUBSTITUTED PYRIDINE COMPOUNDS AND DERIVATIVES THEREOF AS HERBICIDES | ZENECA LTD (GB) | 1999-04-21 | — | — | EP | disclosed |
| US-5763357-A | HERBICIDES | ZENECA LIMITED (GB) | 1998-06-09 | — | — | US | disclosed |
| EP-0758321-A1 | 3-SUBSTITUTED PYRIDINE COMPOUNDS AND DERIVATIVES THEREOF AS HERBICIDES | ZENECA LIMITED (GB) | 1997-02-19 | — | — | EP | disclosed |
| US-5595958-A | HERBICIDES | ZENECA LIMITED (GB) | 1997-01-21 | — | — | US | disclosed |
| WO-1995029893-A1 | 3-SUBSTITUTED PYRIDINE COMPOUNDS AND DERIVATIVES THEREOF AS HERBICIDES | ZENECA LIMITED (GB) | 1995-11-09 | — | — | WO | disclosed |