Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | NT5E | P21589 | 8/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.51 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.47 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.47 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8326734 | 0.89 | ALDH1A1 (0.69) | ALDH1A1LMNATP53MAPTTDP1 | |
| SCHEMBL10689750 | 0.88 | ADORA2A (0.59) | LMNAADORA3ADORA2AADORA1ADORA2B | |
| SCHEMBL9404265 | 0.87 | ALDH1A1 (0.53) | ALDH1A1LMNATP53MAPTTDP1 | |
| SCHEMBL8909878 | 0.87 | ALDH1A1 (0.53) | ALDH1A1LMNATP53MAPTTDP1 | |
| SCHEMBL23436497 | 0.87 | LMNA (0.69) | ALDH1A1LMNATP53MAPTTDP1 | |
| SCHEMBL15679138 | 0.87 | LMNA (0.69) | ALDH1A1LMNATP53MAPTTDP1 | |
| SCHEMBL8818839 | 0.87 | LMNA (0.69) | ALDH1A1LMNATP53MAPTTDP1 | |
| SCHEMBL8819182 | 0.86 | ALDH1A1 (0.51) | ALDH1A1LMNATP53MAPTTDP1 | |
| SCHEMBL9404051 | 0.86 | ALDH1A1 (0.51) | ALDH1A1LMNATP53MAPTTDP1 | |
| SCHEMBL9080632 | 0.85 | ALDH1A1 (0.51) | ALDH1A1LMNATP53MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5925624-A | ANTIINFLAMMATORY AGENTS TREATING PATIENTS WITH INFLAMMATORY CONDITIONS SUSCEPTIBLE TO LEUKOCYTE-INDUCED TISSUE DAMAGE | GLAXO GROUP LIMITED (GB) | 1999-07-20 | — | — | US | disclosed |
| US-5889178-A | N-(2,2-DIPHENYLETHYL)-DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1999-03-30 | — | — | US | disclosed |
| EP-0680488-B1 | 2,6-DIAMINOPURINE DERIVATIVES | GLAXO GROUP LTD (GB) | 1998-04-08 | — | — | EP | disclosed |
| WO-1996002553-A2 | AMINO PURINE-β-D-RIBOFURANURONAMIDE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1996-02-01 | — | — | WO | disclosed |