Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 5/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 2/20 | 0.33 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8328588 | 0.80 | KIF11 (0.45) | KIF11CNR1CNR2CYP19A1TSHR | |
| SCHEMBL8326409 | 0.79 | KIF11 (0.44) | KIF11NPC1RAB9ACYP3A4CYP2D6 | |
| SCHEMBL8320416 | 0.79 | KIF11 (0.44) | KIF11NPC1RAB9ACYP3A4CYP2D6 | |
| SCHEMBL8325626 | 0.78 | KCNN4 (0.43) | KIF11CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL4249887 | 0.77 | TAAR1 (0.46) | CYP3A4CYP2D6CYP2C9CYP2C19KCNN4 | |
| SCHEMBL8329053 | 0.74 | ALDH1A1 (0.56) | KIF11NPC1RAB9ACYP3A4CYP2D6 | |
| SCHEMBL8324979 | 0.73 | TSHR (0.45) | KIF11RAB9ACYP3A4CYP2D6CYP1A2 | |
| SCHEMBL8325767 | 0.72 | KIF11 (0.46) | KIF11CYP3A4TSHR | |
| SCHEMBL530151 | 0.72 | HTT (0.42) | KIF11RAB9ACYP2C19HTTAKR1C3 | |
| SCHEMBL8324574 | 0.71 | KIF11 (0.46) | KIF11CYP3A4CYP2D6KCNH2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948496-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDONE COMPOUNDS AND METHODS OF USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998024780-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDINONE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |