Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.45 |
| ▸ | ELANE | P08246 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MGLL | Q99685 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8791412 | 0.83 | RAB9A (0.75) | RAB9ASMN1; SMN2POLBHSD11B1ELANE | |
| SCHEMBL12988528 | 0.82 | POLB (0.45) | RAB9ASMN1; SMN2POLBHSD11B1ELANE | |
| SCHEMBL8305761 | 0.81 | RAB9A (0.55) | RAB9ASMN1; SMN2POLBELANEPKM | |
| SCHEMBL5256770 | 0.79 | RAB9A (0.53) | RAB9ASMN1; SMN2POLBHSD11B1PKM | |
| SCHEMBL22365579 | 0.79 | MMP1 (0.40) | RAB9APOLBHSD11B1ELANEPKM | |
| SCHEMBL22365578 | 0.79 | MMP1 (0.40) | RAB9APOLBHSD11B1ELANEPKM | |
| SCHEMBL22365621 | 0.79 | MMP1 (0.48) | RAB9AHSD11B1PKMNPC1MAPT | |
| SCHEMBL22147809 | 0.79 | MMP1 (0.48) | RAB9AHSD11B1PKMNPC1MAPT | |
| SCHEMBL6410939 | 0.79 | HSD11B1 (0.53) | RAB9ASMN1; SMN2HSD11B1NPC1MEN1 | |
| SCHEMBL22365581 | 0.78 | LIPE (0.42) | RAB9ASMN1; SMN2POLBHSD11B1ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1592426-B1 | 2-CYANOPYRROLOPYRIMIDINES AND PHARMACEUTICAL USES THEREOF | NOVARTIS AG (CH) | 2007-12-19 | — | — | EP | disclosed |
| WO-2004069256-A1 | 2-CYANOPYRROLOPYRIMIDINES AND PHARMACEUTICAL USES THEREOF | NOVARTIS AG (CH) | 2004-08-19 | — | — | WO | disclosed |