Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8326146 | 0.89 | TP53 (0.48) | POLBKMT2AMEN1ALDH1A1GAA | |
| SCHEMBL8330706 | 0.88 | KMT2A (0.52) | POLBKMT2AMEN1ALDH1A1GAA | |
| SCHEMBL8326334 | 0.88 | KMT2A (0.56) | POLBKMT2AMEN1ALDH1A1GAA | |
| SCHEMBL8329014 | 0.87 | POLB (0.61) | POLBKMT2AMEN1L3MBTL1KDM4E | |
| SCHEMBL8324364 | 0.86 | KMT2A (0.42) | POLBKMT2AMEN1ALDH1A1GAA | |
| SCHEMBL8329545 | 0.85 | CCR3 (0.53) | POLBKMT2AMEN1ALDH1A1GAA | |
| SCHEMBL8330451 | 0.85 | ALDH1A1 (0.49) | POLBKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL7498674 | 0.81 | DRD4 (0.56) | KMT2AMEN1 | |
| SCHEMBL8327678 | 0.77 | KMT2A (0.53) | POLBKMT2AMEN1L3MBTL1KDM4E | |
| SCHEMBL8622621 | 0.76 | KMT2A (0.52) | POLBKMT2AMEN1L3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0760368-B1 | PYRIMIDINE DERIVATIVES | NISSHIN FLOUR MILLING CO (JP) | 1999-07-28 | — | — | EP | disclosed |
| US-5753654-A | GASTROINTESTINAL DISORDERS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1998-05-19 | — | — | US | disclosed |
| US-5736550-A | TREATMENT OF GASTROINTESTINAL TRACT DISORDERS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1998-04-07 | — | — | US | disclosed |
| EP-0760362-A1 | NOVEL DIAMINOMETHYLIDENE DERIVATIVE | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1997-03-05 | — | — | EP | disclosed |
| EP-0760368-A1 | NOVEL PYRIMIDINE DERIVATIVE | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1997-03-05 | — | — | EP | disclosed |