Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | BCHE | P06276 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | CCR3 | P51677 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8326334 | 0.89 | KMT2A (0.56) | ALDH1A1KMT2AMEN1POLBGAA | |
| SCHEMBL8326146 | 0.88 | TP53 (0.48) | ALDH1A1KMT2AMEN1POLBGAA | |
| SCHEMBL8324364 | 0.87 | KMT2A (0.42) | ALDH1A1KMT2AMEN1POLBMAPT | |
| SCHEMBL8327677 | 0.85 | POLB (0.54) | ALDH1A1KMT2AMEN1POLBKDM4E | |
| SCHEMBL8329545 | 0.84 | CCR3 (0.53) | ALDH1A1KMT2AMEN1POLBGAA | |
| SCHEMBL8330706 | 0.83 | KMT2A (0.52) | ALDH1A1KMT2AMEN1POLBGAA | |
| SCHEMBL7501984 | 0.82 | DRD4 (0.49) | ALDH1A1KMT2AMEN1TEAD1LMNA | |
| SCHEMBL8329014 | 0.81 | POLB (0.61) | ALDH1A1KMT2AMEN1POLBKDM4E | |
| SCHEMBL8624170 | 0.77 | ALDH1A1 (0.43) | ALDH1A1KMT2AMEN1POLBMAPT | |
| SCHEMBL8330452 | 0.77 | ALDH1A1 (0.43) | ALDH1A1KMT2AMEN1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0760368-B1 | PYRIMIDINE DERIVATIVES | NISSHIN FLOUR MILLING CO (JP) | 1999-07-28 | — | — | EP | disclosed |
| US-5753654-A | GASTROINTESTINAL DISORDERS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1998-05-19 | — | — | US | disclosed |
| US-5736550-A | TREATMENT OF GASTROINTESTINAL TRACT DISORDERS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1998-04-07 | — | — | US | disclosed |
| EP-0760362-A1 | NOVEL DIAMINOMETHYLIDENE DERIVATIVE | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1997-03-05 | — | — | EP | disclosed |
| EP-0760368-A1 | NOVEL PYRIMIDINE DERIVATIVE | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1997-03-05 | — | — | EP | disclosed |