SCHEMBL8327950

SCHEMBL8327950

CC(=O)OC[C@H]1O[C@@H](n2cc(F)c(=O)[nH]c2=O)C[C@@H]1OCc1ccc(F)cc1F

nearest known ligand 0.47

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
TYMS P04818 1/20 0.42
RNASE1 P07998 1/20 0.40
TK1 P04183 2/20 0.38
NT5E P21589 1/20 0.38
P2RY6 Q15077 1/20 0.38
P2RY14 Q15391 1/20 0.38
ABCG2 Q9UNQ0 3/20 0.37
ABCB1 P08183 1/20 0.37
TSHR P16473 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8327954 1.00 LMNA (0.47) LMNASMN1; SMN2TYMSRNASE1TK1
SCHEMBL8328242 0.92 LMNA (0.46) LMNASMN1; SMN2TYMSRNASE1TK1
SCHEMBL8328237 0.92 LMNA (0.46) LMNASMN1; SMN2TYMSRNASE1TK1
SCHEMBL8329355 0.87 LMNA (0.45) LMNASMN1; SMN2TYMSRNASE1TK1
SCHEMBL8329352 0.87 LMNA (0.45) LMNASMN1; SMN2TYMSRNASE1TK1
SCHEMBL9098319 0.85 TYMS (0.53) LMNASMN1; SMN2TYMSRNASE1TK1
SCHEMBL9098312 0.85 TYMS (0.53) LMNASMN1; SMN2TYMSRNASE1TK1
SCHEMBL8327670 0.83 LMNA (0.48) LMNASMN1; SMN2TYMSRNASE1TK1
SCHEMBL8327674 0.83 LMNA (0.48) LMNASMN1; SMN2TYMSRNASE1TK1
SCHEMBL8329362 0.83 LMNA (0.55) LMNASMN1; SMN2TYMSRNASE1TK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5869464-A HAVING LOW TOXICITY, SUSTAINING LOW CONCENTRATION IN BLOOD FOR EXTENDED PERIOD TAIHO PHARMACEUTICAL CO. LTD. (JP) 1999-02-09 US disclosed
EP-0686641-B1 2'-DEOXY-5-FLUOROURIDINE DERIVATIVE, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PROCESS FOR PRODUCING THE SAME, AND ANTITUMOR DRUG TAIHO PHARMACEUTICAL CO LTD (JP) 1998-08-26 EP disclosed
EP-0686641-A1 2'-DEOXY-5-FLUOROURIDINE DERIVATIVE, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PROCESS FOR PRODUCING THE SAME, AND ANTITUMOR DRUG TAIHO PHARMACEUTICAL CO., LTD. (JP) 1995-12-13 EP disclosed