Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8325160 | 0.83 | MMP8 (0.51) | MMP8TSHRALDH1A1MEN1KMT2A | |
| SCHEMBL2836425 | 0.83 | KMT2A (0.47) | MMP8TSHRALDH1A1MEN1KMT2A | |
| SCHEMBL8323986 | 0.83 | MMP8 (0.44) | MMP8TSHRALDH1A1MEN1KMT2A | |
| SCHEMBL8327982 | 0.82 | TSHR (0.49) | TSHRALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL11436019 | 0.77 | ALDH1A1 (0.45) | MMP8TSHRALDH1A1MEN1KMT2A | |
| SCHEMBL8325804 | 0.76 | MMP8 (0.53) | MMP8TSHRALDH1A1MEN1KMT2A | |
| SCHEMBL9388700 | 0.75 | HTT (0.46) | MMP8TSHRALDH1A1MEN1KMT2A | |
| SCHEMBL1717481 | 0.75 | MMP8 (0.46) | MMP8TSHRALDH1A1MEN1KMT2A | |
| SCHEMBL2836423 | 0.75 | KMT2A (0.50) | MMP8TSHRALDH1A1MEN1KMT2A | |
| SCHEMBL30364408 | 0.74 | NLRP3 (0.47) | TSHRALDH1A1MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0555327-B1 | ALKYLIDENE ANALOGS OF 1'-AMINOSPIRO-[ISOQUINOLINE- 4(1H),3'-PYRROLIDINE]-1,2',3,5'(2H)-TETRONES USEFUL AS ALDOSE REDUCTASE INHIBITORS IN VIVO | AMERICAN HOME PROD (US) | 1999-01-13 | — | — | EP | disclosed |
| EP-0553263-B1 | 1'-AMINOSPIRO-[ISOQUINOLINE-4(1H),3'-PYRROLIDINE]- 1,2',3,5'(2H)-TETRONES AND ANALOGS THEREOF USEFUL AS ALDOSE REDUCTASE INHIBITORS IN VIVO | AMERICAN HOME PROD (US) | 1998-08-05 | — | — | EP | disclosed |
| EP-0555327-A1 | ALKYLIDENE ANALOGS OF 1'-AMINOSPIRO-[ISOQUINOLINE- 4(1H),3'-PYRROLIDINE]-1,2',3,5'(2H)-TETRONES USEFUL AS ALDOSE REDUCTASE INHIBITORS IN VIVO | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-08-18 | — | — | EP | disclosed |
| EP-0553263-A1 | 1'-AMINOSPIRO-[ISOQUINOLINE-4(1H),3'-PYRROLIDINE]- 1,2',3,5'(2H)-TETRONES AND ANALOGS THEREOF USEFUL AS ALDOSE REDUCTASE INHIBITORS IN VIVO | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-08-04 | — | — | EP | disclosed |
| EP-0519600-A1 | Process and intermediate for making isoquinoline derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-12-23 | — | — | EP | disclosed |
| US-5130425-A | Antidiabetic agents spiro azetidine-2,4'(1'H)-isoquinoline! 1',3',4(2'H)-triones | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-07-14 | — | — | US | disclosed |
| WO-1992006974-A1 | ALKYLIDENE ANALOGS OF 1'-AMINOSPIRO[ISOQUINOLINE-4(1H),3'-PYRROLIDINE]-1,2',3,5'(2H)-TETRONES USEFUL AS ALDOSE REDUCTASE INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-04-30 | — | — | WO | disclosed |
| WO-1992006975-A1 | 1'-AMINOSPIRO[ISOQUINOLINE-4(1H),3'-PYRROLIDINE]-1,2',3,5'(2H)-TETRONES AND ANALOGS THEREOF USEFUL AS ALDOSE REDUCTASE INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-04-30 | — | — | WO | disclosed |
| US-5106978-A | Process and intermediates for the preparation of spiro(isoquinoline-4(1H), 3'-pyrrolidine)-1,2', 3,5'(2H)-tetrones which are useful as aldose reductase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-04-21 | — | — | US | disclosed |
| US-5102886-A | 1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones and analogs thereof useful as aldose reductase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-04-07 | — | — | US | disclosed |
| US-5081241-A | Diabetes | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-01-14 | — | — | US | disclosed |
| US-5068332-A | Antidiabetic agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-11-26 | — | — | US | disclosed |