Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3150589 | 0.91 | ATM (0.45) | ATML3MBTL1HTTKDM4EALDH1A1 | |
| SCHEMBL8447698 | 0.81 | TBXAS1 (0.36) | L3MBTL1KDM4ESMN1; SMN2 | |
| SCHEMBL30437453 | 0.76 | KDM4E (0.50) | KDM4EALDH1A1MEN1KMT2ANPSR1 | |
| SCHEMBL3630406 | 0.76 | KDM4E (0.50) | KDM4EALDH1A1MEN1KMT2ANPSR1 | |
| SCHEMBL9384846 | 0.74 | SLC18A3 (0.36) | ATML3MBTL1HTTMEN1KMT2A | |
| SCHEMBL9382269 | 0.74 | L3MBTL1 (0.34) | ATML3MBTL1HTTKDM4EALDH1A1 | |
| SCHEMBL9429930 | 0.73 | HTT (0.44) | ATML3MBTL1HTTKDM4EALDH1A1 | |
| SCHEMBL3156050 | 0.71 | HTT (0.44) | ATML3MBTL1HTTKDM4EALDH1A1 | |
| SCHEMBL9430322 | 0.70 | HTT (0.41) | ATML3MBTL1HTTKDM4EALDH1A1 | |
| SCHEMBL9385160 | 0.69 | L3MBTL1 (0.34) | L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0470490-B1 | Substituted pyrroles | HOFFMANN LA ROCHE (CH) | 1999-05-06 | — | — | EP | disclosed |
| US-5292747-A | Substituted pyrroles | HOFFMAN-LA ROCHE INC. (US) | 1994-03-08 | — | — | US | disclosed |
| EP-0470490-A1 | Substituted pyrroles | F. HOFFMANN-LA ROCHE AG (CH) | 1992-02-12 | — | — | EP | disclosed |