Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.33 |
| ▸ | SLC6A1 | P30531 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8452787 | 0.89 | TBXAS1 (0.36) | TBXAS1SMN1; SMN2RAB9AKDM4ENOTUM | |
| SCHEMBL8328348 | 0.81 | ATM (0.45) | SMN1; SMN2KDM4EL3MBTL1 | |
| SCHEMBL13279285 | 0.80 | MTNR1A (0.43) | SMN1; SMN2RAB9AKDM4EL3MBTL1MAPT | |
| SCHEMBL8325790 | 0.78 | MEN1 (0.38) | SMN1; SMN2RAB9AKDM4ECYP1A2L3MBTL1 | |
| SCHEMBL8454692 | 0.76 | ALDH1A1 (0.34) | SMN1; SMN2RAB9AKDM4ECYP1A2L3MBTL1 | |
| SCHEMBL231853 | 0.76 | PLAU (0.49) | KDM4EMAPT | |
| SCHEMBL9382269 | 0.76 | L3MBTL1 (0.34) | SMN1; SMN2RAB9AKDM4ECYP1A2L3MBTL1 | |
| SCHEMBL9385160 | 0.73 | L3MBTL1 (0.34) | RAB9AL3MBTL1NPC1MAPTAKR1C3 | |
| SCHEMBL9384846 | 0.71 | SLC18A3 (0.36) | L3MBTL1MAPT | |
| SCHEMBL8449850 | 0.71 | DGAT1 (0.45) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0624586-B1 | Substituted pyrroles | HOFFMANN LA ROCHE (CH) | 1999-09-01 | — | — | EP | disclosed |
| EP-0624586-A1 | Substituted pyrroles | F. HOFFMANN-LA ROCHE AG (CH) | 1994-11-17 | — | — | EP | disclosed |