Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 8/20 | 0.50 |
| ▸ | PNMT | P11086 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.37 |
| ▸ | HTR3B | O95264 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.37 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.37 |
| ▸ | KCNN4 | O15554 | 2/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27525548 | 0.82 | KCNN4 (0.52) | KIF11ALDH1A1KCNN4TAAR1 | |
| SCHEMBL8320416 | 0.80 | KIF11 (0.44) | KIF11KCNN4CYP19A1 | |
| SCHEMBL8326409 | 0.80 | KIF11 (0.44) | KIF11KCNN4CYP19A1 | |
| SCHEMBL8323195 | 0.79 | TSHR (0.48) | ALDH1A1KCNN4CYP19A1 | |
| SCHEMBL8322927 | 0.78 | KIF11 (0.49) | KIF11PNMTALDH1A1TAAR1 | |
| SCHEMBL8321573 | 0.78 | KIF11 (0.49) | KIF11KCNN4TAAR1 | |
| SCHEMBL8324380 | 0.78 | KIF11 (0.50) | KIF11KCNN4TAAR1 | |
| SCHEMBL8321948 | 0.78 | KIF11 (0.49) | KIF11KCNN4TAAR1 | |
| SCHEMBL8328588 | 0.76 | KIF11 (0.45) | KIF11ALDH1A1CYP19A1SCN5ASCN9A | |
| SCHEMBL3356661 | 0.75 | ALDH1A1 (0.50) | KIF11PNMTALDH1A1HTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1328277-C | Substituted pyrimidinone and pyridinone compounds and their use | AMGEN INC (US) | 2007-07-25 | — | — | CN | disclosed |
| CN-1246857-A | Substituted pyrimidinone and pyridinone compounds and their use | AMGEN INC (US) | 2000-03-08 | — | — | CN | disclosed |
| EP-0948496-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDONE COMPOUNDS AND METHODS OF USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998024780-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDINONE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |