Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 6/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 6/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | ABHD6 | Q9BV23 | 8/20 | 0.35 |
| ▸ | EP300 | Q09472 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8329197 | 1.00 | ESR1 (0.44) | ESR1ESR2PKMABHD6EP300 | |
| SCHEMBL8325983 | 0.86 | ESR1 (0.48) | ESR1ESR2PKMABHD6EP300 | |
| SCHEMBL8325730 | 0.85 | NOTUM (0.42) | — | |
| SCHEMBL8325734 | 0.85 | NOTUM (0.42) | — | |
| SCHEMBL8325697 | 0.79 | MAOA (0.34) | — | |
| SCHEMBL8325695 | 0.79 | MAOA (0.34) | — | |
| SCHEMBL29516561 | 0.73 | PARP1 (0.46) | — | |
| SCHEMBL8328965 | 0.72 | ALDH1A1 (0.30) | — | |
| SCHEMBL8330143 | 0.72 | CD274 (0.37) | — | |
| SCHEMBL8330144 | 0.72 | CD274 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0529636-B1 | Novel isatinoxime derivatives, their preparation and use | NEUROSEARCH AS (DK) | 1999-06-23 | — | — | EP | disclosed |
| US-5436250-A | Isatineoxime derivatives, their preparation and use | NEUROSEARCH A/S (DK) | 1995-07-25 | — | — | US | disclosed |
| US-5242918-A | Isatinoxime derivatives, their preparation and use | NEUROSEARCH A/S (DK) | 1993-09-07 | — | — | US | disclosed |
| WO-1993005043-A1 | NOVEL ISATINOXIME DERIVATIVES, THEIR PREPARATION AND USE | NEUROSEARCH A/S (DK) | 1993-03-18 | — | — | WO | disclosed |
| EP-0529636-A1 | Novel isatinoxime derivatives, their preparation and use | NEUROSEARCH A/S (DK) | 1993-03-03 | — | — | EP | disclosed |