Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 9/20 | 0.55 |
| ▸ | HSP90AB1 | P08238 | 9/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ADCY10 | Q96PN6 | 11/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29094518 | 0.83 | ALOX15 (0.41) | HSP90AA1HSP90AB1KDM4E | |
| SCHEMBL29094466 | 0.77 | ALOX15 (0.37) | HSP90AA1HSP90AB1KDM4E | |
| SCHEMBL29094580 | 0.76 | ALOX15 (0.39) | HSP90AA1HSP90AB1KDM4E | |
| SCHEMBL3952089 | 0.70 | HSP90AA1 (0.70) | HSP90AA1HSP90AB1KDM4EADCY10 | |
| SCHEMBL29571104 | 0.70 | HSP90AA1 (0.70) | HSP90AA1HSP90AB1KDM4EADCY10 | |
| SCHEMBL22501986 | 0.69 | HSP90AA1 (0.66) | HSP90AA1HSP90AB1KDM4EADCY10 | |
| SCHEMBL439225 | 0.69 | KDM4E (0.49) | KDM4E | |
| SCHEMBL29094509 | 0.69 | ALDH1A1 (0.44) | KDM4E | |
| SCHEMBL1643108 | 0.68 | HSP90AA1 (1.00) | HSP90AA1HSP90AB1KDM4E | |
| Hydrochloric Acid SCHEMBL22502036 | 0.68 | HSP90AA1 (0.64) | HSP90AA1HSP90AB1KDM4EADCY10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7737153-B2 | Heteroaryloxy-substituted phenylaminopyrimidines as rho-kinase inhibitors | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-06-15 | — | — | US | disclosed |
| US-7737153-B2 | Heteroaryloxy-substituted phenylaminopyrimidines as rho-kinase inhibitors | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-06-15 | — | — | US | disclosed |
| WO-2004039796-A1 | HETEROARYLOXY-SUBSTITUTED PHENYLAMINOPYRIMIDINES AS RHO-KINASE INHIBITORS | BAYER HEALTHCARE AG (DE) | 2004-05-13 | — | — | WO | disclosed |