SCHEMBL8329240

SCHEMBL8329240

O=C(O)c1ccccc1-c1cc2ccccc2nc1C(=O)O

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.56
KDM4E B2RXH2 3/20 0.56
MEN1 O00255 3/20 0.56
KMT2A Q03164 3/20 0.56
SMN1; SMN2 Q16637 2/20 0.52
MAPT P10636 1/20 0.52
RAB9A P51151 4/20 0.48
RECQL P46063 1/20 0.44
NPC1 O15118 3/20 0.44
HSD17B10 Q99714 1/20 0.43
FOLH1 Q04609 1/20 0.43
MGAM O43451 2/20 0.42
CYP2C9 P11712 2/20 0.42
CYP3A4 P08684 1/20 0.42
ALOX12 P18054 1/20 0.42
SOS1 Q07889 1/20 0.42
IKBKB O14920 1/20 0.41
TP53 P04637 1/20 0.41
CYP1A2 P05177 1/20 0.41
HPGD P15428 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4602438 0.84 ALDH1A1 (0.53) ALDH1A1KDM4EMEN1KMT2ASMN1; SMN2
SCHEMBL2001891 0.81 ALDH1A1 (0.57) ALDH1A1KDM4EMEN1KMT2ASMN1; SMN2
SCHEMBL70017 0.81 ALDH1A1 (0.61) ALDH1A1KDM4EMEN1KMT2ASMN1; SMN2
SCHEMBL30034075 0.81 ALDH1A1 (0.61) ALDH1A1KDM4EMEN1KMT2ASMN1; SMN2
SCHEMBL3296316 0.81 KMT2A (0.54) ALDH1A1KDM4EMEN1KMT2ASMN1; SMN2
Water SCHEMBL10472756 0.80 ALDH1A1 (0.59) ALDH1A1KDM4EMEN1KMT2ASMN1; SMN2
Hydrochloric Acid SCHEMBL9622111 0.80 ALDH1A1 (0.59) ALDH1A1KDM4EMEN1KMT2ASMN1; SMN2
SCHEMBL28389068 0.80 ALDH1A1 (0.59) ALDH1A1KDM4EMEN1KMT2ASMN1; SMN2
Water SCHEMBL10410161 0.80 ALDH1A1 (0.59) ALDH1A1KDM4EMEN1KMT2ASMN1; SMN2
SCHEMBL498189 0.79 HSD17B10 (0.55) ALDH1A1KDM4ESMN1; SMN2MAPTHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0709377-B1 Process for producing quinolin-2-yl benzoic acid compounds ASAHI GLASS CO LTD (JP) 1999-09-29 EP disclosed
EP-0709377-A1 Process for producing quinolin-2-yl benzoic acid compounds ASAHI GLASS COMPANY LTD. (JP) 1996-05-01 EP disclosed