Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | PIM1 | P11309 | 3/20 | 0.47 |
| ▸ | GLA | P06280 | 2/20 | 0.43 |
| ▸ | MGAM | O43451 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | STAT3 | P40763 | 1/20 | 0.42 |
| ▸ | GUSB | P08236 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.39 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.39 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8329240 | 0.84 | ALDH1A1 (0.56) | ALDH1A1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL2001891 | 0.81 | ALDH1A1 (0.57) | ALDH1A1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL60874 | 0.81 | ALDH1A1 (0.61) | ALDH1A1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL5031687 | 0.78 | MCL1 (0.52) | ALDH1A1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL625363 | 0.78 | ALDH1A1 (0.49) | ALDH1A1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL11089095 | 0.75 | KDM4E (0.50) | ALDH1A1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL31556386 | 0.75 | KDM4E (0.50) | ALDH1A1KDM4EMEN1KMT2AMAPT | |
| Pyridine SCHEMBL2285312 | 0.75 | ALDH1A1 (0.50) | ALDH1A1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL27790153 | 0.75 | KDM4E (0.54) | ALDH1A1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL70017 | 0.74 | ALDH1A1 (0.61) | ALDH1A1KDM4EMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1915363-A1 | OXOPYRIDYL QUINOLINE AMIDES AS NK3 RECEPTOR MODULATORS | AstraZeneca AB (SE) | 2008-04-30 | — | — | EP | disclosed |
| WO-2007018469-A1 | OXOPYRIDYL QUINOLINE AMIDES AS NK3 RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2007-02-15 | — | — | WO | disclosed |