Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 4/20 | 0.49 |
| ▸ | RARB | P10826 | 4/20 | 0.49 |
| ▸ | RARG | P13631 | 4/20 | 0.49 |
| ▸ | SYK | P43405 | 2/20 | 0.37 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 2/20 | 0.32 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8327517 | 0.92 | RARA (0.40) | RARARARBRARGSYKPTPN11 | |
| SCHEMBL8331032 | 0.87 | RARA (0.53) | RARARARBRARGSYKNPC1 | |
| SCHEMBL8469320 | 0.83 | RARA (0.42) | RARARARBRARGSYKPTPN11 | |
| SCHEMBL8330182 | 0.73 | RARA (0.47) | RARARARBRARGIDO1MCL1 | |
| SCHEMBL8331248 | 0.73 | RARB (0.38) | RARARARBRARG | |
| SCHEMBL1140826 | 0.72 | RARB (0.60) | RARARARBRARGNPC1RAB9A | |
| SCHEMBL6593199 | 0.71 | RARA (0.49) | RARARARBRARG | |
| SCHEMBL8329653 | 0.71 | RARA (0.37) | RARARARBRARGNPC1GAA | |
| SCHEMBL8329823 | 0.71 | RARA (0.46) | RARARARBRARGIDO1POLB | |
| SCHEMBL6589951 | 0.70 | RARA (0.64) | RARARARBRARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5958954-A | 2,2-DIALKYL-4-ARYL-SUBSTITUTED BENZOPYRAN AND BENZOTHIOPYRAN DERIVATIVES | ALLERGAN SALES, INC. (US) | 1999-09-28 | — | — | US | disclosed |