Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | RET | P07949 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8327462 | 0.76 | TSHR (0.39) | ALDH1A1PKMIDO1TSHRGAA | |
| SCHEMBL8326439 | 0.71 | ALDH1A1 (0.42) | ALDH1A1PKMIDO1TSHRGAA | |
| Bromide SCHEMBL8327518 | 0.65 | MEN1 (0.38) | ALDH1A1GAALMNAHTT | |
| SCHEMBL4259200 | 0.63 | PRMT5 (0.57) | ALDH1A1PKMTSHRSMN1; SMN2LMNA | |
| SCHEMBL8325690 | 0.63 | ATP4A (0.47) | GAAKDM4EHTT | |
| SCHEMBL8329254 | 0.63 | CYP11B1 (0.35) | ALDH1A1PKMTSHRGAAKDM4E | |
| SCHEMBL8329568 | 0.58 | KDM4E (0.39) | PKMIDO1TSHRKDM4EHTT | |
| SCHEMBL9130426 | 0.58 | IDO1 (0.47) | ALDH1A1PKMIDO1TSHRGAA | |
| SCHEMBL11518221 | 0.58 | ALDH1A1 (0.52) | ALDH1A1PKMTSHRGAASMN1; SMN2 | |
| SCHEMBL31292178 | 0.56 | DPP4 (0.32) | ALDH1A1KDM4ELMNAHTTDPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0509974-B1 | Pyrrolo[2,3-b]pyridines having therapeutic activity and a process for the preparation thereof | ASTRA AB (SE) | 1999-01-13 | — | — | EP | disclosed |
| US-5439917-A | Phenyl-pyrrolo(2,3-b)pyridine antisecretory agent of gastric acid; adenosine triphosphatase enzyme inhibitor | AKTIEBOLAGET ASTRA (SE) | 1995-08-08 | — | — | US | disclosed |
| EP-0580616-A1 | NEW ACTIVE COMPOUNDS | Astra Aktiebolag (SE) | 1994-02-02 | — | — | EP | disclosed |
| EP-0509974-A1 | Pyrrolo[2,3-b]pyridines having therapeutic activity and a process for the preparation thereof | Astra Aktiebolag (SE) | 1992-10-21 | — | — | EP | disclosed |
| WO-1992017477-A1 | NEW ACTIVE COMPOUNDS | AKTIEBOLAGET ASTRA (SE) | 1992-10-15 | — | — | WO | disclosed |