Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11151250 | 0.74 | SIGMAR1 (0.40) | IDO1 | |
| SCHEMBL11154742 | 0.73 | HTR7 (0.41) | IDO1ALDH1A1MEN1KMT2A | |
| SCHEMBL10147161 | 0.71 | CYP19A1 (0.42) | — | |
| SCHEMBL6496747 | 0.70 | CYP11B1 (0.63) | IDO1 | |
| SCHEMBL11271642 | 0.70 | CYP11B1 (0.52) | IDO1LMNASMN1; SMN2 | |
| SCHEMBL10299417 | 0.68 | TSHR (0.51) | ALDH1A1TSHRGAALMNAMEN1 | |
| SCHEMBL6989844 | 0.68 | TSHR (0.48) | IDO1ALDH1A1TSHR | |
| SCHEMBL11518221 | 0.68 | ALDH1A1 (0.52) | ALDH1A1TSHRGAALMNAPKM | |
| SCHEMBL6173273 | 0.67 | CYP19A1 (0.71) | — | |
| SCHEMBL7783933 | 0.67 | TSHR (0.58) | ALDH1A1TSHRLMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5468743-A | Imidazo[2,1-b]benzazepine derivatives, compositions and method of use | JANSSEN PHARMACEUTICA N.V. (BE) | 1995-11-21 | — | — | US | disclosed |
| EP-0588858-A1 | IMIDAZO 2,1-b] 3]BENZAZEPINE DERIVATIVES, COMPOSITIONS AND METHOD OF USE | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-03-30 | — | — | EP | disclosed |
| WO-1992022551-A1 | IMIDAZO[2,1-b][3]BENZAZEPINE DERIVATIVES, COMPOSITIONS AND METHOD OF USE | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-12-23 | — | — | WO | disclosed |