Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | KCNA5 | P22460 | 5/20 | 0.38 |
| ▸ | GCK | P35557 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | PTAFR | P25105 | 7/20 | 0.36 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | VNN1 | O95497 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8330140 | 1.00 | NAMPT (0.38) | NAMPTKCNA5GCKHDAC8PTAFR | |
| SCHEMBL8327721 | 0.84 | CYP3A4 (0.43) | ALDH1A1 | |
| SCHEMBL8178611 | 0.78 | LPAR1 (0.37) | KCNA5ALDH1A1DPP4HTT | |
| SCHEMBL8178607 | 0.78 | LPAR1 (0.37) | KCNA5ALDH1A1DPP4HTT | |
| SCHEMBL6674115 | 0.76 | LMNA (0.38) | KCNA5ALDH1A1DPP4HTT | |
| SCHEMBL6674119 | 0.76 | LMNA (0.38) | KCNA5ALDH1A1DPP4HTT | |
| SCHEMBL6958416 | 0.67 | MRGPRX4 (0.37) | DPP4HTT | |
| SCHEMBL6958407 | 0.67 | MRGPRX4 (0.37) | DPP4HTT | |
| SCHEMBL4022440 | 0.66 | CASP1 (0.41) | ALDH1A1 | |
| SCHEMBL8328849 | 0.66 | KDM6B (0.50) | NAMPTHDAC8PTAFRALDH1A1VNN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0869787-A4 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 1999-03-24 | — | — | EP | disclosed |
| EP-0869787-A1 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-10-14 | — | — | EP | disclosed |
| WO-1997024119-A1 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-07-10 | — | — | WO | disclosed |