Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 8/20 | 0.37 |
| ▸ | LPAR5 | Q9H1C0 | 8/20 | 0.37 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 2/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.32 |
| ▸ | PLA2G2D | Q9UNK4 | 1/20 | 0.31 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8178611 | 1.00 | LPAR1 (0.37) | LPAR1LPAR5MRGPRX4LMNAMAPK1 | |
| SCHEMBL6674119 | 0.84 | LMNA (0.38) | LPAR1LPAR5MRGPRX4LMNAMAPK1 | |
| SCHEMBL6674115 | 0.84 | LMNA (0.38) | LPAR1LPAR5MRGPRX4LMNAMAPK1 | |
| SCHEMBL8183267 | 0.79 | CTSL (0.40) | ALDH1A1 | |
| SCHEMBL8183264 | 0.79 | CTSL (0.40) | ALDH1A1 | |
| SCHEMBL8330140 | 0.78 | NAMPT (0.38) | HTTDPP4ALDH1A1KCNA5 | |
| SCHEMBL8330137 | 0.78 | NAMPT (0.38) | HTTDPP4ALDH1A1KCNA5 | |
| SCHEMBL6958407 | 0.74 | MRGPRX4 (0.37) | MRGPRX4LMNAMAPK1HTTRAB9A | |
| SCHEMBL6958416 | 0.74 | MRGPRX4 (0.37) | MRGPRX4LMNAMAPK1HTTRAB9A | |
| SCHEMBL8326411 | 0.67 | LPAR1 (0.38) | LPAR1LPAR5HTTRAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6159964-A | Vitronectin receptor antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 2000-12-12 | — | — | US | disclosed |
| EP-0906103-A4 | — | — | 1999-04-07 | — | — | EP | disclosed |
| EP-0906103-A1 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-04-07 | — | — | EP | disclosed |
| WO-1997024124-A1 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-07-10 | — | — | WO | disclosed |