SCHEMBL8330895

SCHEMBL8330895

CCC#Cc1ccc2c(c1)C(c1ccc(CC)cc1)=CC(C)(C)S2

nearest known ligand 0.39

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
RARA P10276 2/20 0.39
RARB P10826 2/20 0.39
RARG P13631 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8334015 0.89 RARA (0.43) RARARARBRARG
SCHEMBL13784637 0.87 RARA (0.42) RARARARBRARG
SCHEMBL726359 0.82 RARA (0.60) RARARARBRARG
SCHEMBL6592216 0.78 RARA (0.40) RARARARBRARG
SCHEMBL6596743 0.76 CYP3A4 (0.49) RARARARBRARG
SCHEMBL6591838 0.74 RARA (0.56) RARARARBRARG
SCHEMBL1140826 0.73 RARB (0.60) RARARARBRARG
SCHEMBL8331998 0.71 RARA (0.32) RARARARBRARG
SCHEMBL6596136 0.69 RARB (0.46) RARARARBRARG
SCHEMBL8327517 0.68 RARA (0.40) RARARARBRARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5958954-A 2,2-DIALKYL-4-ARYL-SUBSTITUTED BENZOPYRAN AND BENZOTHIOPYRAN DERIVATIVES ALLERGAN SALES, INC. (US) 1999-09-28 US disclosed