Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | COMT | P21964 | 2/20 | 0.36 |
| ▸ | CCR2 | P41597 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8327247 | 0.82 | PARP1 (0.46) | GAASMN1; SMN2FEN1ALDH1A1KDM4E | |
| SCHEMBL8327401 | 0.82 | GAA (0.39) | GAASMN1; SMN2FEN1ALDH1A1KDM4E | |
| SCHEMBL8327356 | 0.81 | GAA (0.38) | GAASMN1; SMN2FEN1ALDH1A1KDM4E | |
| SCHEMBL8712895 | 0.80 | FEN1 (0.41) | GAASMN1; SMN2FEN1ALDH1A1KDM4E | |
| SCHEMBL8328463 | 0.77 | SMN1; SMN2 (0.35) | GAASMN1; SMN2FEN1ALDH1A1KDM4E | |
| SCHEMBL8324966 | 0.77 | CACNA1G (0.39) | GAASMN1; SMN2FEN1ALDH1A1BCHE | |
| Bromide SCHEMBL844133 | 0.71 | MGAM (0.47) | GAAALDH1A1 | |
| SCHEMBL7073865 | 0.68 | MAPT (0.61) | GAASMN1; SMN2ALDH1A1KDM4ECOMT | |
| SCHEMBL5859159 | 0.67 | KDM4E (0.39) | GAASMN1; SMN2ALDH1A1KDM4EKMT2A | |
| SCHEMBL7451781 | 0.67 | DRD4 (0.37) | GAASMN1; SMN2ALDH1A1KMT2ACHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0869787-A4 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 1999-03-24 | — | — | EP | disclosed |
| EP-0869787-A1 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-10-14 | — | — | EP | disclosed |
| WO-1997024119-A1 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-07-10 | — | — | WO | disclosed |