Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | COMT | P21964 | 1/20 | 0.33 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.33 |
| ▸ | TDP2 | O95551 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | UBE2I | P63279 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8327356 | 0.85 | GAA (0.38) | GAASMN1; SMN2FEN1ALDH1A1KDM4E | |
| SCHEMBL8331002 | 0.82 | GAA (0.43) | GAASMN1; SMN2FEN1ALDH1A1KDM4E | |
| SCHEMBL8327247 | 0.78 | PARP1 (0.46) | GAASMN1; SMN2FEN1ALDH1A1KDM4E | |
| SCHEMBL8328463 | 0.77 | SMN1; SMN2 (0.35) | GAASMN1; SMN2FEN1ALDH1A1KDM4E | |
| SCHEMBL8712895 | 0.75 | FEN1 (0.41) | GAASMN1; SMN2FEN1ALDH1A1KDM4E | |
| SCHEMBL8324966 | 0.72 | CACNA1G (0.39) | GAASMN1; SMN2FEN1ALDH1A1LMNA | |
| SCHEMBL8327253 | 0.71 | SMN1; SMN2 (0.36) | GAASMN1; SMN2FEN1ALDH1A1LMNA | |
| SCHEMBL9434820 | 0.67 | CHEK1 (0.39) | SMN1; SMN2ALDH1A1KDM4EPOLBHPGD | |
| SCHEMBL8322003 | 0.64 | POLB (0.66) | GAAPOLBBCHEKMT2AMEN1 | |
| SCHEMBL7073865 | 0.64 | MAPT (0.61) | GAASMN1; SMN2ALDH1A1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0869787-A4 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 1999-03-24 | — | — | EP | disclosed |
| EP-0869787-A1 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-10-14 | — | — | EP | disclosed |
| WO-1997024119-A1 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-07-10 | — | — | WO | disclosed |