Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1G | O43497 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 2/20 | 0.36 |
| ▸ | CCR2 | P41597 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | STAT5B | P51692 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.33 |
| ▸ | COMT | P21964 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8331002 | 0.77 | GAA (0.43) | CCR2SMN1; SMN2GAACHEK1FEN1 | |
| SCHEMBL8327247 | 0.73 | PARP1 (0.46) | SMN1; SMN2GAAFEN1ALDH1A1COMT | |
| SCHEMBL8327401 | 0.72 | GAA (0.39) | SMN1; SMN2GAACHEK1FEN1LMNA | |
| SCHEMBL6943657 | 0.72 | CACNA1G (0.57) | CACNA1GCACNA1BCACNA1CSMN1; SMN2GAA | |
| SCHEMBL8328463 | 0.72 | SMN1; SMN2 (0.35) | CCR2SMN1; SMN2GAACHEK1FEN1 | |
| SCHEMBL8327356 | 0.72 | GAA (0.38) | SMN1; SMN2GAAFEN1LMNAALDH1A1 | |
| SCHEMBL8712895 | 0.71 | FEN1 (0.41) | SMN1; SMN2GAAFEN1ALDH1A1COMT | |
| SCHEMBL16186544 | 0.69 | CACNA1G (0.56) | CACNA1GCACNA1BCACNA1CCHEK1CACNA1H | |
| SCHEMBL8324888 | 0.69 | CACNA1G (0.53) | CACNA1GCACNA1BCACNA1CSMN1; SMN2GAA | |
| SCHEMBL8327253 | 0.69 | SMN1; SMN2 (0.36) | CCR2SMN1; SMN2GAAFEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0869787-A4 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 1999-03-24 | — | — | EP | disclosed |
| EP-0869787-A1 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-10-14 | — | — | EP | disclosed |
| WO-1997024119-A1 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-07-10 | — | — | WO | disclosed |