Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | COMT | P21964 | 5/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPY1R | P25929 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8327247 | 0.86 | PARP1 (0.46) | FEN1GAAKDM4EALDH1A1EGFR | |
| SCHEMBL8331002 | 0.80 | GAA (0.43) | FEN1GAAKDM4EALDH1A1EGFR | |
| SCHEMBL8034262 | 0.79 | PTGS1 (0.37) | GAAKDM4EKMT2AMAPT | |
| SCHEMBL11327139 | 0.78 | DUSP5 (0.35) | KDM4E | |
| Silver SCHEMBL9320049 | 0.78 | PARP1 (0.33) | KDM4E | |
| SCHEMBL989259 | 0.76 | L3MBTL1 (0.40) | KDM4ECOMT | |
| SCHEMBL8327401 | 0.75 | GAA (0.39) | FEN1GAAKDM4EALDH1A1EGFR | |
| SCHEMBL8327356 | 0.74 | GAA (0.38) | FEN1GAAKDM4EALDH1A1EGFR | |
| SCHEMBL8324966 | 0.71 | CACNA1G (0.39) | FEN1GAAALDH1A1COMTMEN1 | |
| SCHEMBL8328463 | 0.71 | SMN1; SMN2 (0.35) | FEN1GAAKDM4EALDH1A1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |