Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 12/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | RAD52 | P43351 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NOS3 | P29474 | 2/20 | 0.39 |
| ▸ | NOS1 | P29475 | 2/20 | 0.39 |
| ▸ | NOS2 | P35228 | 2/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.37 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6727713 | 0.77 | SIGMAR1 (0.70) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| Hydrochloric Acid SCHEMBL7211128 | 0.76 | SIGMAR1 (0.72) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL11877875 | 0.75 | PLAU (0.50) | PLAUSIGMAR1RAD52NOS3NOS1 | |
| Hydrochloric Acid SCHEMBL7205189 | 0.75 | SIGMAR1 (0.82) | SIGMAR1MEN1KMT2AMAPT | |
| SCHEMBL6716818 | 0.72 | SIGMAR1 (0.59) | SIGMAR1MEN1KMT2AGRIN2DGRIN3B | |
| SCHEMBL11879382 | 0.72 | HTR3E (0.47) | PLAUALDH1A1ADRA2AADRA2BADRA2C | |
| Hydrochloric Acid SCHEMBL9045265 | 0.71 | PLAU (0.43) | PLAUSIGMAR1NOS3NOS1NOS2 | |
| SCHEMBL4798301 | 0.69 | TRPA1 (0.46) | SMN1; SMN2ALDH1A1NOS3NOS1NOS2 | |
| SCHEMBL28277786 | 0.69 | RAB9A (0.49) | SMN1; SMN2ALDH1A1HTTTRPA1KDM4E | |
| SCHEMBL10208289 | 0.69 | TRPA1 (0.64) | SMN1; SMN2ALDH1A1TRPA1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999002145-A1 | COMBINATION DRUG THERAPIES COMPRISING AMINOGLYCOSIDE ANTIBIOTICS AND N,N'-DISUBSTITUTED GUANIDINES | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1999-01-21 | — | — | WO | disclosed |