SCHEMBL8332355

SCHEMBL8332355

CC(C)(C)n1c(=O)[nH]n(C(=O)c2ccccc2)c1=O

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GSK3A P49840 1/20 0.42
GSK3B P49841 1/20 0.42
TYMP P19971 1/20 0.40
POLB P06746 1/20 0.36
SIGMAR1 Q99720 1/20 0.36
ENPP3 O14638 2/20 0.36
ALPL P05186 2/20 0.36
XIAP P98170 2/20 0.36
LMNA P02545 1/20 0.36
MAPT P10636 1/20 0.36
HSD17B10 Q99714 1/20 0.36
DAO P14920 2/20 0.35
TSHR P16473 1/20 0.35
NAPRT Q6XQN6 1/20 0.35
P2RX4 Q99571 1/20 0.35
HPGD P15428 1/20 0.34
ACHE P22303 1/20 0.34
NPC1 O15118 1/20 0.34
RAB9A P51151 1/20 0.34
KMT2A Q03164 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9472573 0.72 MAPT (0.48) GSK3AGSK3BPOLBLMNAMAPT
SCHEMBL9473275 0.71 ALDH1A1 (0.43) LMNAHSD17B10TSHRHPGDKMT2A
SCHEMBL9474918 0.68 CES2 (0.47) GSK3AGSK3BPOLBLMNAMAPT
SCHEMBL31466054 0.66 TYMP (0.58) GSK3AGSK3BTYMPPOLBSIGMAR1
SCHEMBL11792243 0.63 P2RX4 (0.59) GSK3AGSK3BTYMPPOLBSIGMAR1
SCHEMBL3015728 0.63 TYMP (0.54) GSK3AGSK3BTYMPSIGMAR1DAO
Benzoic Acid SCHEMBL7999427 0.62 TSHR (0.78) HSD17B10DAOTSHRNAPRT
SCHEMBL3676684 0.62 SIGMAR1 (0.42) GSK3AGSK3BTYMPSIGMAR1ENPP3
SCHEMBL11424477 0.62 CA1 (0.69) TSHRP2RX4ACHE
Benzoic Acid SCHEMBL27562905 0.61 TSHR (0.74) HSD17B10DAOTSHRNAPRT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1999001607-A2 ENZYMATIC OXIDATION SYSTEM WITH NOVEL ENZYMATIC-EFFECT ENHANCING COMPOUNDS CALL, KRIMHILD (DE) 1999-01-14 WO disclosed