Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 4/20 | 0.49 |
| ▸ | HTR2A | P28223 | 2/20 | 0.49 |
| ▸ | HTR2B | P41595 | 2/20 | 0.49 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 3/20 | 0.40 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8330683 | 0.85 | HTR2A (0.49) | HTR2CHTR2AHTR2BSLC9A1CHRM2 | |
| SCHEMBL8332789 | 0.80 | SLC9A1 (0.51) | HTR2CHTR2AHTR2BSLC9A1CHRM2 | |
| SCHEMBL8329351 | 0.80 | HTR2A (0.47) | HTR2CHTR2AHTR2BSLC9A1CHRM2 | |
| SCHEMBL8332882 | 0.80 | HTR2A (0.47) | HTR2CHTR2AHTR2BSLC9A1CHRM2 | |
| SCHEMBL8330285 | 0.80 | HSD17B1 (0.48) | HTR2CHTR2AHTR2BSLC9A1CHRM2 | |
| SCHEMBL8332123 | 0.79 | HTR2A (0.48) | HTR2CHTR2AHTR2BSLC9A1CHRM2 | |
| SCHEMBL8891603 | 0.78 | HTR2C (0.56) | HTR2CHTR2AHTR2BSLC9A1CHRM2 | |
| SCHEMBL8334785 | 0.77 | SLC9A1 (0.48) | HTR2CHTR2AHTR2BSLC9A1CHRM2 | |
| SCHEMBL8332239 | 0.77 | SLC9A1 (0.48) | HTR2CHTR2AHTR2BSLC9A1CHRM2 | |
| SCHEMBL8891319 | 0.76 | HTR2A (0.54) | HTR2CHTR2AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5889031-A | CONTROLLING CIRCADIAN RHYTHMS | BRISTOL-MYERS SQUIBB COMPNAY (US) | 1999-03-30 | — | — | US | disclosed |
| US-5753709-A | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-05-19 | — | — | US | disclosed |