Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | HRAS | P01112 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8072121 | 0.81 | SMN1; SMN2 (0.41) | NPC1SMN1; SMN2RAB9AKMT2AALDH1A1 | |
| SCHEMBL5700649 | 0.79 | ALDH1A1 (0.42) | NPC1SMN1; SMN2RAB9AKMT2AALDH1A1 | |
| SCHEMBL8332629 | 0.74 | SMN1; SMN2 (0.43) | NPC1SMN1; SMN2RAB9AKMT2AALDH1A1 | |
| SCHEMBL8332753 | 0.73 | SMN1; SMN2 (0.34) | NPC1SMN1; SMN2RAB9AKMT2AALDH1A1 | |
| SCHEMBL8331629 | 0.73 | ALDH1A1 (0.48) | NPC1SMN1; SMN2RAB9AKMT2AALDH1A1 | |
| SCHEMBL8469094 | 0.71 | NPSR1 (0.40) | NPC1SMN1; SMN2RAB9AKMT2AALDH1A1 | |
| SCHEMBL7156545 | 0.70 | ALDH1A1 (0.40) | NPC1SMN1; SMN2RAB9AKMT2AALDH1A1 | |
| SCHEMBL14946791 | 0.70 | KIF11 (0.43) | KMT2AMEN1 | |
| SCHEMBL9098372 | 0.69 | ALDH1A1 (0.47) | NPC1SMN1; SMN2RAB9AKMT2AALDH1A1 | |
| SCHEMBL12061890 | 0.68 | KIF11 (0.44) | NPC1SMN1; SMN2RAB9AKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5919917-A | WITH NUCLEOTIDE SEQUENCE CAPABLE OF HYBRIDIZATION TO TARGET NUCLEIC ACID AFTER DECYCLIZATION; EXONUCLEASE AND ENDONUCLEASE RESISTANT; FOR ANTISENSE GENE THERAPY | LABORATORY OF MOLECULAR BIOPHOTONICS (JP) | 1999-07-06 | — | — | US | disclosed |
| EP-0855403-A1 | PHOTOCLEAVABLE CYCLIC OLIGONUCLEOTIDE | Laboratory of Molecular Biophotonics (JP) | 1998-07-29 | — | — | EP | disclosed |