Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPY1R | P25929 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPY2R | P49146 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29451221 | 0.82 | SMN1; SMN2 (0.43) | SMN1; SMN2NPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL9098372 | 0.80 | ALDH1A1 (0.47) | SMN1; SMN2NPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL8072121 | 0.78 | SMN1; SMN2 (0.41) | SMN1; SMN2NPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL9098377 | 0.77 | MAOB (0.47) | SMN1; SMN2NPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL4948735 | 0.77 | SMN1; SMN2 (0.43) | SMN1; SMN2NPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL5700649 | 0.76 | ALDH1A1 (0.42) | SMN1; SMN2NPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL24937040 | 0.75 | LMNA (0.46) | KMT2ALMNAKIF11 | |
| SCHEMBL10434128 | 0.75 | LMNA (0.46) | KMT2ALMNAKIF11 | |
| SCHEMBL10434091 | 0.75 | LMNA (0.46) | KMT2ALMNAKIF11 | |
| SCHEMBL25713808 | 0.74 | KIF11 (0.51) | SMN1; SMN2KMT2AALDH1A1GAAKIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5919917-A | WITH NUCLEOTIDE SEQUENCE CAPABLE OF HYBRIDIZATION TO TARGET NUCLEIC ACID AFTER DECYCLIZATION; EXONUCLEASE AND ENDONUCLEASE RESISTANT; FOR ANTISENSE GENE THERAPY | LABORATORY OF MOLECULAR BIOPHOTONICS (JP) | 1999-07-06 | — | — | US | disclosed |
| EP-0543889-B1 | INCORPORATION OF SELECTABLY CLEVABLE SITES INTO OLIGONUCLEOTIDE CHAINS AND REAGENTS THEREFOR | CHIRON CORP (US) | 1999-04-21 | — | — | EP | disclosed |
| EP-0900805-A2 | Incorporation of selectably cleavable and/or abasic sites into oligonucleotide chains and reagents therefor | CHIRON CORPORATION (US) | 1999-03-10 | — | — | EP | disclosed |
| EP-0855403-A1 | PHOTOCLEAVABLE CYCLIC OLIGONUCLEOTIDE | Laboratory of Molecular Biophotonics (JP) | 1998-07-29 | — | — | EP | disclosed |
| US-5578717-A | Nucleotides for introducing selectably cleavable and/or abasic sites into oligonucleotides | CHIRON CORPORATION (US) | 1996-11-26 | — | — | US | disclosed |
| US-5545730-A | Multifunctional nucleic acid monomer | CHIRON CORPORATION (US) | 1996-08-13 | — | — | US | disclosed |
| US-5430136-A | Oligonucleotides having selectably cleavable and/or abasic sites | CHIRON CORPORATION (US) | 1995-07-04 | — | — | US | disclosed |
| US-5367066-A | Oligonucleotides with selectably cleavable and/or abasic sites | CHIRON CORPORATION (US) | 1994-11-22 | — | — | US | disclosed |
| US-5258506-A | Photolabile reagents for incorporation into oligonucleotide chains | CHIRON CORPORATION (US) | 1993-11-02 | — | — | US | disclosed |