Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.41 |
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5700649 | 0.89 | ALDH1A1 (0.42) | SMN1; SMN2NPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL8332829 | 0.81 | NPC1 (0.38) | SMN1; SMN2NPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL8332629 | 0.78 | SMN1; SMN2 (0.43) | SMN1; SMN2NPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL18802219 | 0.78 | ALDH1A1 (0.46) | SMN1; SMN2NPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL9098372 | 0.76 | ALDH1A1 (0.47) | SMN1; SMN2NPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL4424977 | 0.74 | KIF11 (0.43) | KMT2AALDH1A1KIF11MAPK1MEN1 | |
| SCHEMBL29451221 | 0.73 | SMN1; SMN2 (0.43) | SMN1; SMN2NPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL17928455 | 0.73 | KIF11 (0.46) | SMN1; SMN2KMT2AALDH1A1LMNAKIF11 | |
| SCHEMBL8332753 | 0.73 | SMN1; SMN2 (0.34) | SMN1; SMN2NPC1RAB9AKMT2AALDH1A1 | |
| Nitrophenolate SCHEMBL28864273 | 0.72 | SMN1; SMN2 (0.47) | SMN1; SMN2NPC1RAB9AKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6124445-A | PRO DRUGS FOR OLIGONUCLEOTIDES HAVING BIOREVERSIBLE PHOSPHATE BLOCKING GROUPS | ISIS PHARMACEUTICALS, INC. (US) | 2000-09-26 | — | — | US | disclosed |
| US-5955591-A | OLIGONUCLEOTIDES HAVING BIOREVERSIBLE PHOSPHATE BLOCKING GROUPS; USED AS PRODRUGS; ANTISENSE AGENTS | CENTER NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 1999-09-21 | — | — | US | disclosed |