Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8393917 | 0.92 | ALDH1A1 (0.40) | ALDH1A1P2RX2MEN1KMT2ALMNA | |
| SCHEMBL8339579 | 0.90 | LMNA (0.36) | ALDH1A1P2RX2MEN1KMT2ALMNA | |
| SCHEMBL8341309 | 0.76 | ALDH1A1 (0.38) | ALDH1A1P2RX2MEN1KMT2ALMNA | |
| SCHEMBL8336897 | 0.75 | TDP1 (0.39) | ALDH1A1MEN1KMT2ATDP1MAPT | |
| SCHEMBL8392591 | 0.70 | ALDH1A1 (0.39) | ALDH1A1P2RX2MEN1KMT2ALMNA | |
| SCHEMBL8333062 | 0.69 | GAA (0.36) | ALDH1A1P2RX2MEN1KMT2AP2RX7 | |
| SCHEMBL8334261 | 0.68 | CNR2 (0.39) | MEN1KMT2ALMNACNR2MAPT | |
| SCHEMBL8341312 | 0.66 | POLB (0.38) | ALDH1A1P2RX2MEN1KMT2ALMNA | |
| SCHEMBL8339583 | 0.65 | — | — | |
| SCHEMBL8341128 | 0.65 | CNR2 (0.36) | ALDH1A1P2RX2MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977177-A | Substituted benzenesulfonylureas and-thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds, and medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-11-02 | — | — | US | disclosed |
| US-5880155-A | TREATMENT OF CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-03-09 | — | — | US | disclosed |