Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 11/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.48 |
| ▸ | KDM1B | Q8NB78 | 2/20 | 0.48 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.39 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8716294 | 0.86 | ALOX5 (0.34) | KDM1ASLC9A1ALOX5HTR2AHTR2C | |
| SCHEMBL8333860 | 0.81 | KDM1A (0.35) | KDM1AKCNH2KDM1BHTR2AHTR2C | |
| SCHEMBL8332822 | 0.81 | KDM1A (0.46) | KDM1ARCOR1ALOX5HTR2AHTR2C | |
| SCHEMBL8331485 | 0.81 | HTR2A (0.44) | KDM1ARCOR1ALOX5HTR2AHTR2C | |
| SCHEMBL8335022 | 0.77 | KDM1A (0.47) | KDM1AKDM1BHTR2AHTR2CHTR2B | |
| SCHEMBL8331608 | 0.77 | HTR2A (0.45) | KDM1AALOX5HTR2AHTR2CHTR2B | |
| SCHEMBL8331361 | 0.77 | HTR2A (0.45) | KDM1AALOX5KIF11HTR2AHTR2C | |
| SCHEMBL8332794 | 0.76 | SLC9A1 (0.47) | SLC9A1ALOX5HTR2AHTR2CHTR2B | |
| SCHEMBL8716974 | 0.74 | SLC6A2 (0.36) | KDM1AALOX5 | |
| SCHEMBL8332303 | 0.74 | ADAM17 (0.38) | KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5889031-A | CONTROLLING CIRCADIAN RHYTHMS | BRISTOL-MYERS SQUIBB COMPNAY (US) | 1999-03-30 | — | — | US | disclosed |
| US-5753709-A | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-05-19 | — | — | US | disclosed |