SCHEMBL8335117

SCHEMBL8335117

Cc1c(N)cc(Cl)cc1Cl

nearest known ligand 0.46

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 9/20 0.46
ALDH1A1 P00352 5/20 0.46
TSHR P16473 6/20 0.44
TP53 P04637 2/20 0.44
CD44 P16070 1/20 0.44
GAA P10253 2/20 0.41
SMN1; SMN2 Q16637 3/20 0.40
ALOX15 P16050 2/20 0.40
TDP1 Q9NUW8 1/20 0.40
HSD17B10 Q99714 2/20 0.38
PIK3CA P42336 1/20 0.38
RECQL P46063 1/20 0.38
HPGD P15428 1/20 0.36
ALOX12 P18054 1/20 0.36
MAPK1 P28482 1/20 0.36
KMT2A Q03164 1/20 0.35
HTT P42858 1/20 0.35
RAPGEF4 Q8WZA2 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3671147 0.92 CYP3A4 (0.52) CYP3A4ALDH1A1TSHRTP53CD44
SCHEMBL11251495 0.84 CYP3A4 (0.48) CYP3A4ALDH1A1TSHRTP53CD44
SCHEMBL98117 0.80 ALDH1A1 (0.53) CYP3A4ALDH1A1TSHRTP53CD44
SCHEMBL11229241 0.79 CYP3A4 (0.52) CYP3A4ALDH1A1TSHRTP53CD44
SCHEMBL2963949 0.79 ALDH1A1 (0.46) CYP3A4ALDH1A1TSHRTP53CD44
SCHEMBL345827 0.79 CYP3A4 (0.50) CYP3A4ALDH1A1TSHRTP53CD44
SCHEMBL29434817 0.79 ALDH1A1 (0.46) CYP3A4ALDH1A1TSHRTP53CD44
SCHEMBL28514732 0.77 ALDH1A1 (0.50) CYP3A4ALDH1A1TSHRTP53CD44
SCHEMBL16728590 0.77 ALDH1A1 (0.44) CYP3A4ALDH1A1TSHRCD44GAA
SCHEMBL1466729 0.75 CYP3A4 (0.43) CYP3A4ALDH1A1TSHRTP53CD44

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5998595-A Azidohalogenobenzyl derivatives, sugar compounds and protection of hydroxy groups WAKO PURE CHEMICAL INDUSTRIES, LTD. (JP) 1999-12-07 US disclosed
US-4431585-A THIAZOLE AND THIOPHENE DYES; DIAZOTIZATION; COUPLING CASSELLA AKTIENGESELLSCHAFT (DE) 1984-02-14 US disclosed
EP-0038439-B1 DYESTUFF MIXTURES, METHOD FOR THEIR PREPARATION, THE COMPONENT DYESTUFFS AND THEIR USE IN DYEING AND PRINTING SYNTHETIC, HYDROPHOBIC FIBRE MATERIAL CASSELLA Aktiengesellschaft (DE) 1983-05-04 EP disclosed
US-4329283-A DISPERSE DYES BAYER AKTIENGESELLSCHAFT (DE) 1982-05-11 US disclosed
US-4297297-A α-Cyano-β-(substituted-anilino)-N-ethoxycarbonylacrylamide intermediates ZOECON CORP. (US) 1981-10-27 US disclosed
EP-0035671-A1 Water-insoluble azo dyestuffs, methods for their preparation and their use in dyeing and printing synthetic hydrophobic fibre materials CASSELLA Aktiengesellschaft (DE) 1981-09-16 EP disclosed
US-4267382-A ANTITUMOR AGENTS; SKIN DISORDERS HOFFMANN-LA ROCHE INC. (US) 1981-05-12 US disclosed
US-4266056-A FUNGICIDES, BACTERICIDES ZOECON CORPORATION (US) 1981-05-05 US disclosed
US-4247456-A Water-insoluble monoazo pyridone dye CASSELLA AKTIENGESELLSCHAFT (DE) 1981-01-27 US disclosed
US-4225527-A TREATMENT OF DERMATOLOGICAL CONDITIONS HOFFMANN-LA ROCHE INC. (US) 1980-09-30 US disclosed
US-4201707-A Methine dyestuffs containing a phenyl azo group BAYER AKTIENGESELLSCHAFT (DE) 1980-05-06 US disclosed
US-4156086-A INTERMEDIATES FOR AZO DYES BAYER AKTIENGESELLSCHAFT (DE) 1979-05-22 US disclosed
US-4138570-A METHINE DYE BAYER AKTIENGESELLSCHAFT (DE) 1979-02-06 US disclosed
US-4038268-A DIAZOTIZATION, COUPLING BAYER AKTIENGESELLSCHAFT (DT) 1977-07-26 US disclosed
US-4006128-A CELLULOSE ACETATES, VINYL POLYMERS, POLYOLEFINS, POLYESTERS BAYER AKTIENGESELLSCHAFT (DT) 1977-02-01 US disclosed