Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.48 |
| ▸ | MEN1 | O00255 | 6/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.41 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9819817 | 0.74 | NPC1 (0.57) | KMT2AMEN1RAB9ANPC1ALDH1A1 | |
| SCHEMBL8425970 | 0.71 | ALDH1A1 (0.45) | KMT2AMEN1RAB9ANPC1ALDH1A1 | |
| SCHEMBL6720855 | 0.71 | SIGMAR1 (0.44) | KMT2AMEN1RAB9ANPC1ALDH1A1 | |
| SCHEMBL9628907 | 0.67 | SIGMAR1 (0.71) | KMT2AMEN1RAB9ANPC1ALDH1A1 | |
| SCHEMBL3679747 | 0.67 | NPC1 (0.68) | KMT2AMEN1RAB9ANPC1ALDH1A1 | |
| SCHEMBL30260457 | 0.67 | NPC1 (0.68) | KMT2AMEN1RAB9ANPC1ALDH1A1 | |
| SCHEMBL17724353 | 0.66 | ALDH1A1 (0.66) | KMT2AMEN1RAB9ANPC1ALDH1A1 | |
| SCHEMBL10577866 | 0.66 | KDM4E (0.51) | KMT2AMEN1RAB9ANPC1ALDH1A1 | |
| SCHEMBL30323639 | 0.66 | KDM4E (0.51) | KMT2AMEN1RAB9ANPC1ALDH1A1 | |
| SCHEMBL15856404 | 0.66 | CYP2A6 (0.58) | ALDH1A1KDM4EHPGDCYP1A2CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999002145-A1 | COMBINATION DRUG THERAPIES COMPRISING AMINOGLYCOSIDE ANTIBIOTICS AND N,N'-DISUBSTITUTED GUANIDINES | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1999-01-21 | — | — | WO | disclosed |