Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.30 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.30 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8339395 | 0.97 | TSHR (0.31) | TSHRALDH1A1HTTNPSR1MAOA | |
| SCHEMBL8339176 | 0.81 | OPRM1 (0.39) | TSHRHTTSLC6A3SLC6A2SLC6A4 | |
| SCHEMBL8335797 | 0.78 | OPRK1 (0.41) | ALDH1A1SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL8340005 | 0.77 | DRD3 (0.31) | TSHRALDH1A1HTT | |
| SCHEMBL8340115 | 0.76 | CFB (0.34) | EPHX2 | |
| SCHEMBL8340296 | 0.66 | TACR1 (0.35) | TSHRALDH1A1HTT | |
| SCHEMBL8340904 | 0.65 | GAA (0.33) | ALDH1A1 | |
| SCHEMBL8339028 | 0.63 | GAA (0.33) | ALDH1A1HTT | |
| SCHEMBL8336415 | 0.61 | SMN1; SMN2 (0.33) | ALDH1A1HTT | |
| SCHEMBL8339453 | 0.61 | TSHR (0.35) | TSHRHTTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977177-A | Substituted benzenesulfonylureas and-thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds, and medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-11-02 | — | — | US | disclosed |
| US-5880155-A | TREATMENT OF CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-03-09 | — | — | US | disclosed |