Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 2/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SCD5 | Q86SK9 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8339176 | 0.97 | OPRM1 (0.39) | OPRK1OPRM1HSD17B10BACE1KDM4E | |
| SCHEMBL8339013 | 0.79 | CNR2 (0.33) | CYP1A2CYP3A4CYP2C9PKMCYP2C19 | |
| SCHEMBL8335763 | 0.78 | TSHR (0.35) | ALDH1A1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8336462 | 0.71 | OPRK1 (0.39) | OPRK1OPRM1HSD17B10KDM4EALDH1A1 | |
| SCHEMBL8340115 | 0.69 | CFB (0.34) | — | |
| SCHEMBL8338913 | 0.68 | SMN1; SMN2 (0.36) | OPRK1OPRM1ALDH1A1MEN1KMT2A | |
| SCHEMBL24775507 | 0.68 | HSD17B10 (0.50) | HSD17B10SCN3AKDM4EALDH1A1MEN1 | |
| SCHEMBL28836843 | 0.67 | OPRK1 (0.55) | OPRK1OPRM1HSD17B10KDM4EALDH1A1 | |
| SCHEMBL8339477 | 0.65 | GPR88 (0.40) | ALDH1A1MEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL11512488 | 0.65 | HSD17B10 (0.48) | OPRK1OPRM1HSD17B10SCN3AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977177-A | Substituted benzenesulfonylureas and-thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds, and medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-11-02 | — | — | US | disclosed |
| US-5880155-A | TREATMENT OF CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-03-09 | — | — | US | disclosed |